Released on = May 21, 2007, 11:04 am

Press Release Author = AnaSpec Inc.

Industry = Biotech

Press Release Summary = The insulin receptor is a transmembrane receptor that
belongs to the tyrosine kinase receptors class.

Press Release Body = May 22, 2007 - San Jose, CA

The insulin receptor is a transmembrane receptor that belongs to the tyrosine kinase
receptors class. It is a heterotetrameric glycoprotein composed of disulfide-linked
subunits in a β-α-α-β configuration. This transmembrane receptor
consists of 95kDa β-subunit, a single transmembrane domain, and 135kDa
α-subunit, which is completely extracellular. Binding of insulin to the
receptor results in stimulation of its intrinsic kinase activity. The insulin
receptor mediates insulin action through the phosphorylation of substrate proteins.
Insulin receptor becomes phosphorylated as a response to stimulation of cells by
insulin, insulin-like growth factor (IGF-I) and interleukin 4. The major substrates
of the insulin receptor kinase are the insulin receptor substrate (IRS) family of
proteins, IRS-1, IRS-2, IRS-3, IRS-4. Recently, two more signaling proteins,
IRS5/DOK4 and IRS6/DOK5, have been identified as potentially new members of the IRS
family. The insulin receptor substrate-1 (IRS-1), a 170-185 kDa protein, is a major
substrate of the insulin receptor. IRS-1 is phosphorylated on serine, threonine and
tyrosine residues in a variety of tissues.

AnaSpec offers a line of insulin receptor antibodies that targets researchers
working in protein phosphorylation, glucose metabolism, cancer, and diabetes
studies. These antibodies are validated on ELISA, and Western Blot or IHC, and
offered in research-grade size.

For more information visit www.anaspec.com

Company Info

AnaSpec, Inc. is a leading provider of integrated proteomics solutions to
pharmaceutical, biotech, and academic research institutions throughout the world.
With a vision for innovation through synergy, AnaSpec focuses on three core
technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and
combinatorial chemistry. Established in 1993, AnaSpec\'s ISO9001:2000 certified
headquarters and manufacturing facilities are located in San Jose, CA.







Web Site = http://www.anaspec.com

Contact Details = 2149 O\'toole Ave.
San Jose, CA 95131
ping@anaspec.com